Pope Celestine I was the bishop of Rome from 10 September 422 to his death on 27 July 432. Celestine's pontificate was largely spent combatting various teachings deemed heretical. He was instrumental in the condemnation of Nestorius in the Council of Ephesus when Cyril of Alexandria appealed him to make a decision; in response, Celestine delegated to Cyril the job of condemning Nestorius if he did not recant his teachings. He supported the mission of the Gallic bishops that sent Germanus of Auxerre in 429, to Britain to address Pelagianism, and later commissioned Palladius as bishop to the Scots of Ireland and northern Britain.

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