Paphnutius of Thebes, also known as Paphnutius the Confessor, was a dubiously historical early Christian figure, said to be a disciple of Anthony the Great and a bishop of a city in the Upper Thebaid in the early fourth century. He is accounted by some as a prominent member of the First Council of Nicaea which took place in 325. Neither the name of his see nor the precise date of his death are known.

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